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Request for Applications 2022-054: MATRIX Technology Accelerator Domain 1

This RFA has been completed.  No further applications will be accepted…

This is an opportunity to apply for funding to advance research applications for development of new HIV prevention approaches. Applicants from a wide range of US, Kenyan, South African, and Zimbabwean institutions are invited to apply to this request for applications sponsored by the Microbicide R&D to Advance HIV Prevention Technologies through Responsive Innovation and eXcellence (MATRIX) consortium and United States Agency for International Development. We are seeking innovative research applications for the development of new HIV prevention drug and strategies, multipurpose prevention technologies (MPTs), and technologies that enable HIV prevention strategy development and have the potential to strengthen capacity in targeted countries. Established researchers, research consortia, students, postdoctoral fellows, and new investigators establishing laboratories and/or seeking tenure from the United States, Kenya, South Africa, and Zimbabwe are encouraged to apply. Proposed research must be driven by milestones, go/no-go criteria, and timelines, and must target development of HIV prevention for one or more of the following populations: adolescent girls and young women, pregnant and breastfeeding women, and female sex workers. Applications are limited to projects with costs of US$150,000 and a duration of 18 months. PATH, a member of the MATRIX consortium, will oversee the application submission and award processes using an oversight structure that draws from US- and Africa-based administrators.

Instructions on how to apply and templates for the application are below:

Key dates

Release of request for applications December 1, 2022 (8:00 a.m. Pacific time)
Letter of intent due February 1, 2023 (8:00 a.m. Pacific time)
Fact-finding questions due February 1, 2023 (8:00 a.m. Pacific time)
Applicants provided responses to fact-finding questions February 15, 2023 (8:00 a.m. Pacific time)
Applications due March 10, 2023 (8:00 a.m. Pacific time)
Applicants notified of decision May 10, 2023 (8:00 a.m. Pacific time)
Estimated project start date June 1, 2023









Note that MATRIX reserves the right to modify this schedule as needed. Parties who express interest will be notified by email of any changes.

This request for applications expires on March 11, 2023.

RFA 2022-054 Instructions on How to Apply
Instructions (Download) 2022-12-01464.28 KB
Answers to fact-finding questions (Download) 2023-02-0367.98 KB
Fact‐finding questions cost sharing update (Download) 2023-03-08118.96 KB